Ozone applied as a medical treatment consists in a mixture of oxygen and ozone that can be administered with the aim of relieving pain. It is believed to have antioxidant, anti-inflammatory and immunomodulatory properties. Ozone therapy may be a treatment option in those patients who have persistent low back pain or neck pain with no response to conventional medical or surgical procedures. It is usually applied intramuscularly and intradiscally. The number and frequency of sessions may vary depending on each patient. Its application has no side effects.